Lentivirus based on HIV-1 provides a powerful means for gene expression because it can infect both dividing and non-dividing cells. Other 3rd generation lentiviral packaging systems provide a reduced risk of replication-competent virus, but a small risk remains.

Our new ViraSafe™ Universal Lentivirus Expression System provides a safer method even compared to 3rd generation expression systems. Overlap with native HIV genes has been reduced much further, thereby substantially reducing the chance of generating replication-competent virus. The system has been engineered so that titers remain at the high levels of third generation systems.

Figure 1: Lentivirus Production using the ViraSafe™ Lentivirus Expression System.