LDL, so-called "bad cholesterol", is even more dangerous when it becomes oxidized. Oxidized LDL (OxLDL) is more reactive with surrounding tissues and can collect within the inner-lining of arteries. Macrophages, cholesterol, and other lipids can accumulate at the site (atherosclerosis), ultimately forming a plaque that can lead to heart attack, stroke or death. Oxidation of LDL affects both the lipid and protein components of LDL.
The OxiSelect™ Human Oxidized LDL ELISA Kits are enzyme immunoassays developed for the detection and quantitation of human oxLDL in plasma, serum or other biological fluid samples. The kits contain a copper oxidized LDL standard against which unknown samples may be compared. This oxidized LDL assay kit is configured to selectively measure oxLDL in HNE-LDL.
Figure 1: Assay Principle for the OxiSelect™ Oxidized LDL ELISA Kits.