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Lentiviral Expression Systems
Lentiviral Expression and Packaging
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- Significantly reduced homology compared to other 3rd generation expression systems for added safety, without loss of titer
- Vectors provided individually to allow optimization of vector ratio
- Universal system allows you to clone a promoter along with your gene of interest for maximum expression levels
- Complete Expression System contains packaging plasmids and transfer vector
Lentivirus based on HIV-1 provides a powerful means for gene expression because it can infect both dividing and non-dividing cells. Other 3rd generation lentiviral packaging systems provide a reduced risk of replication-competent virus, but a small risk remains.
Our new ViraSafe™ Universal Lentivirus Expression System provides a safer method even compared to 3rd generation expression systems. Overlap with native HIV genes has been reduced much further, thereby substantially reducing the chance of generating replication-competent virus. The system has been engineered so that titers remain at the high levels of third generation systems.
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Figure 1: Lentivirus Production using the ViraSafe™ Lentivirus Expression System.
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Chen, M. et al. (2002). Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa. Nature Genetics 32(4):670-675. (VPK-211-PAN)
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