Advanced glycation end products (AGE) are formed during the Maillard reaction where reducing carbohydrates react with lysine side chains and N-terminal amino groups of various macromolecules, particularly proteins (Figure 1). The advanced glycation end products can adversely affect the fuction of these macromolecules. One of the most prevalent AGE products, N-epsilon-(Carboxymethyl) Lysine, has been implicated in oxidative stress and vascular damage.
The OxiSelect™ Methylglyoxal (MG) ELISA Kit detects and quantifies MG protein adducts. MG has been found to be involved in various pathological processes, for example, MG derivatives are found elevated in diabetes.
