Myeloperoxidase Activity Assays

Myeloperoxidase Assays

Myeloperoxidase (MPO) is a heme-based peroxidase enzyme that has been implicated in many disease states, and elevated MPO levels have been linked to coronary artery disease. In the presence of hydrogen peroxide, myeloperoxidase is converted to an active redox intermediary form (MPO-I). From there the enzyme plays two roles: a chlorination reaction by way of conversion of chloride ions to hypochlorous acid, and a peroxidation reaction where it is ultimately converted back to its native state.