AAV-DJ was engineered via DNA family shuffling technology which created a hybrid capsid from 8 AAV serotypes. This resulting vector mediates superior in vitro transduction efficiencies in comparison with any other wild type serotypes and higher infectivity rates across a broad range of cells and tissue types. AAV-DJ/8 is a mutant of AAV-DJ that exhibits increased uptake in brain tissue in vivo, similar to AAV-8 and AAV-9. For more information, click here.

Our new Radius™ Cell Migration Assays utilize a proprietary biocompatible hydrogel spotted in the center of each well of a 24-well or 96-well cell culture plate. The gel creates a circular cell-free zone where cells do not attach. Following gel removal, migratory cells move toward the center and close the gap.  Radius™ assays may be used with any cells of any size and allow both endpoint and real-time analysis. For more information, click here.

While previous assays only allowed you to detect total ROS and RNS from intact cells, our OxiSelect™ In Vitro ROS/RNS Assay is suitable for use with serum, plasma, urine, cell lysates or cell culture supernatants. This assay employs a proprietary fluorogenic probe, DCFH-DiOxyQ; the probe is primed with a dequenching reagent to the highly reactive DCFH form. In the presence of ROS and RNS, the DCFH is rapidly oxidized to the highly fluorescent DCF. For more information, click here.

The AAV Helper Free System was developed to make production of AAV safer and more convenient.  It absolutely eliminates the need for adenovirus transduction! Instead the adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) and in the 293 packaging cells (E1). The overall system includes 2 packaging vectors (pAAV-RC2 and pHelper), a GFP control vector, and your choice of 5 different expression vectors. For more information, click here.