Viral Expression

Viral Expression

Recombinant viruses are excellent tools for the introduction of genetic material into host cells. Each virus differs in how it infects cells and replicates:

  • Adenoviruses can infect a variety of mammalian cell types with high efficiency. They remain epichromosal upon infection, so they are only suitable for transient expression.
  • Adeno-Associated Virus (AAV) integrates into the host cell genome at a very specific site in one human chromosome; random insertions are very rare, making it less immunogenic than adenovirus or retrovirus.
  • Retroviruses (e.g. MMLV) introduce genetic material into the genome of the host cell, allowing long-term stable expression. Retroviral titer is typically lower than that of adenovirus.
  • Lentiviruses (e.g. HIV-1, FIVSIV) are a sub-class of retroviruses that can be used for both transient and stable gene expression; they can infect both proliferating and non-proliferating cells.

Select your Recombinant Virus for Gene Delivery

We have developed a variety of tools to improve the results of your viral expression studies. Our systems will take you from start to finish:

  • Viral Packaging Systems
  • Cell Lines designed for superior viral expression
  • Premade Gene-Specific Viruses and Plasmids
  • Virus Concentration and Purification Kits
  • Viral Titer/Quantitation Kits
  •  Viral Transduction Reagents

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