DNA may be modified in a variety of ways. DNA methylation has been shown to be involved with almost every biological process, and global DNA methylation levels may be associated with various disease states. Other DNA modifications such as oxidative DNA damage have been implicated in the development of a variety of cancers including colon, breast and prostate. Mutations to checkpoint kinases can ultimately lead to decreased DNA repair and increased susceptibility to cancer.
Recently oxidative RNA damage has been described in conjunction with a wide variety of neurological diseases including Alzheimer’s disease, Parkinson’s disease, and Dementia with Lewy Bodies.
We have developed quick and reliable assays to detect global DNA methylation as well as various types of RNA and DNA damage.