Cell Contraction Assays, Floating Matrix Model

Cell Contraction Assays, Floating Matrix Model
  • Proprietary contraction plate eliminates release step
  • Uses 3D collagen matrix to measure changes in collagen gel size
  • Includes optional cell contraction inhibitor
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CytoSelect™ 24-Well Cell Contraction Assay Kit (Floating Matrix Model)
Catalog Number
CBA-5020
Size
24 assays
Detection
Light Microscopy
Manual/Data Sheet Download
SDS Download
Price
$455.00
CytoSelect™ 48-Well Cell Contraction Assay Kit
Catalog Number
CBA-5021
Size
48 assays
Detection
Light Microscopy
Manual/Data Sheet Download
SDS Download
Price
$520.00
Product Details

In the floating matrix contraction model, a freshly polymerized collagen matrix containing cells is released from the culture dish and allowed to float in culture medium, and contraction occursin the absence of external mechanical load and without appearanceof stress fibers in the cells.

Cell Biolabs’ Cell Contraction Assays (Floating Matrix Model) provide a simple, in vitro system to assess cell contractivity and screen cell contraction mediators.  The  proprietary Cell Contraction Plate eliminates the matrix releasing step of the conventional contraction assay, providing a faster, higher-throughput method to assess cell contraction.

Recent Product Citations
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  2. Prosseda, P.P. et al. (2020). Optogenetic stimulation of phosphoinositides reveals a critical role of primary cilia in eye pressure regulation. Sci Adv. doi: 10.1126/sciadv.aay8699 (#CBA-5020).
  3. Manetti, M. et al. (2019). Systemic Sclerosis Serum Steers the Differentiation of Adipose-Derived Stem Cells Toward Profibrotic Myofibroblasts: Pathophysiologic Implications. J Clin Med. 8(8). pii: E1256. doi: 10.3390/jcm8081256 (#CBA-5020).
  4. Duan, F.F. et al. (2019). P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-β1, -β2, and -β3 Translation. Am J Respir Cell Mol Biol. 60(2):221-231. doi: 10.1165/rcmb.2018-0028OC (#CBA-5020).
  5. An, S. et al. (2019). Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies. Ocul Surf. pii: S1542-0124(19)30051-5. doi: 10.1016/j.jtos.2019.03.010 (#CBA-5020).
  6. Iwasaki, K. et al. (2019). Spontaneous differentiation of periodontal ligament stem cells into myofibroblast during ex vivo expansion. J Cell Physiol. doi: 10.1002/jcp.28639 (#CBA-5020).
  7. Li, S. et al. (2019). TRPA1 Promotes Cardiac Myofibroblast Transdifferentiation after Myocardial Infarction Injury via the Calcineurin-NFAT-DYRK1A Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2019:1-17. doi:10.1155/2019/6408352 (#CBA-5021).