Hexosaminidase is an enzyme localized to cellular lysosomes and is typically present as a dimer of alpha and/or beta subunits. The alpha/beta dimer specifically hydrolyzes GM2 gangliosides in vivo. Deficiency in this enzyme leads to a buildup of GM2 gangliosides which is the hallmark of Tay-Sachs disease.
Our Beta Hexosaminidase Activity Assay Kit is a simple fluorometric assay that measures beta hexosaminidase activity in a 96-well microtiter plate format. Each kit provides sufficient reagents to perform up to 100 assays, including blanks, positive control and unknown samples.