Cdc42 Activation Assays

Our Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of Cdc42 protein. The precipitated small GTPase is then detected by Western blot using a Cdc42-specific antibody included in the kit.

If you are also studying Rac1 or RhoA, you may consider one of our economical combination kits.

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2. Aldinucci, A. et al. (2016). Histamine regulates actin cytoskeleton in human Toll like receptor 4 activated monocyte derived dendritic cells tuning CD4+ T lymphocyte response. J Biol Chem. doi:10.1074/jbc.M116.720680 (#STA-402).
3. Sherchan, P. et al. (2015). Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model. Neurobiol Dis. 85:164-173 (#STA-402).
4. Sahu, M. et al. (2014). Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia. Exp Eye Res. 118:125-134 (#STA-402).
5. El-Sayed, F.G. et al. (2014).  P2Y₂ Nucleotide Receptor Activation Enhances the Aggregation and Self-Organization of Dispersed Salivary Epithelial Cells.  Am J Physiol Cell Physiol. 307: C83-C96 (#STA-402).
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9. Tanaka, U. et al. (2015). Sprouty2 inhibition promotes proliferation and migration of periodontal ligament cells. Oral Dis. doi:10.1111/odi.12369 (#STA-404).
10. Holmes,K.M.et al.(2012).Insulin-Like Growth Factor-Binding Protein 2-Driven Glioma Progression is Prevented by Blocking a Clinically Significant Integrin, Integrin-Linked Kinase, and NF-B Network.Proc Natl Acad Sci 109:2168-2173(#STA-404).
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12. Chen, H. et al. (2010). Integrity of SOS1/EPS8/ABI1 Tri-Complex Determines Ovarian Cancer Metastasis. Cancer Res. 70:9979-9990 (#STA-404).
13. Pandey, D. et al. (2009). Unraveling a Novel Rac1-Mediated Signaling Pathway that Regulates Cofilin Dephosphorylation and Secretion in Thrombin Stimulated Platelets. Blood 114:415-424 (#STA-404).
14. Lorger, M. et al. (2006). Regulation of Epithelial Wound Closure and Intercellular Adhesion by Interaction of AF6 with Actin Cytoskeleton. J. of Cell Science 119:3385-3398 (#STA-404).
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16. Le, L. T. et al. (2016). Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness. J Cell Biol. 212:707-719 (#STA-405).
17. Mori, H. et al. (2015). Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P 3 signaling axis. Am J Pathol.  doi:10.1016/j.ajpath.2015.06.015 (#STA-405).
18. Nasrallah, A. et al. (2014). Effect of StarD13 on colorectal cancer proliferation, motility and invasion. Oncol Rep. 31:505-515 (#STA-405).
19. Luis-Ravelo, D. et al. (2014). RHOB influences lung adenocarcinoma metastasis and resistance in a host-sensitive manner. Mol Oncol. 8:196-206 (#STA-405).
20. Khalil, B. D. et al. (2014). The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility. Exp Cell Res. 321:109-122 (#STA-405).
21. Hanna, S. et al. (2014). StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion. Int J Oncol. 44:1499-1511 (#STA-405).
22. Wang, J. et al. (2013). DEK Depletion Negatively Regulates Rho/ROCK/MLC Pathway in Non–Small Cell Lung Cancer. Journal of Histochemistry & Cytochemistry. 10.1369/0022155413488120 (#STA-405).
23. Quint, P. et al. (2013). Sphingosine 1-Phosphate (S1P) Receptors 1 and 2 Coordinately Induce Mesenchymal Cell Migration through S1P Activation of Complementary Kinase Pathways. J. Biol. Chem. 288:5398-5406 (#STA-405).
24. Yu, X. et al. (2012). RhoGDI SUMOylation at Lys-138 Increases Its Binding Activity to Rho GTPase and Its Inhibiting Cancer Cell Motility. J.Biol. Chem. 287:13752-13760 (#STA-405).
25. Baranwai, S. et al. (2011). Molecular Characterization of the Tumor-Suppressive Function of Nischarin in Breast Cancer. J. Natl Cancer Inst. 10.1093/jnci/djr350 (#STA-405).
26. Tian, D. et al. (2010). Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels. Sci. Signal. 3:ra77 (#STA-405).
27. Ma, T. el al. (2010). Viral G Protein-Coupled Receptor Up-Regulates Angiopoietin-like 4 Promoting Angiogenesis and Vascular Permeability in Kaposi's Aarcoma. PNAS. 104:14363-14368. (#STA-405).
28. Xu, Y. et al. (2010). Neuropilin-2 Mediates VEGF-C-Induced Lymphatic Sprouting Together with VEGFR3. J. Cell Biol. 188:115130 (#STA-405).
29. Mohseni, M. et al. (2008). The Headpiece Domain of Dematin Regulates Cell Shape, Motility, and Wound Healing by Modulating RhoA Activity. Mol. Cell. Biol. 28:4712-4718 (#STA-405).
30. Liu, Y. et al. (2008). Ganglioside Depletion and EGF Responses of Human GM3 Synthase-Deficient Fibroblasts. Glycobiology 18:593-601 (#STA-405).
31. Qu, Y. et al. (2008). Enhanced mMgration and CXCR4 Over-Expression in Fibroblasts with Telomerase Reconstitution. Mol. and Cell. Biochem. 313:45-52 (#STA-405).