Lentiviral Expression and Packaging

When packaging lentivirus with your gene of interest, it is important to bear in mind three main considerations: safety, titer, and flexibility. Our lentiviral systems provide a superior level of all three:

  1. Safety: Our ViraSafe™ Lentiviral Expression Systems are specifically engineered to minimize the chance of making replication-competent lentivirus (RCL). The ViraSafe™ technology goes beyond other 3rd generation systems with sequence homology reduced an additional 80-90%, while still using transfection of four plasmids.
  2. Titer: ViraSafe™ technology incorporates unique elements that provide lentiviral titers greater than or equal to those provided by other 3rd generation systems.
  3. Flexibility: We offer the most flexible, open lentiviral system commercially available. Our packaging plasmids are provided individually, not premixed, to allow optimization of vector ratios. In addition, we give you the flexibility to use certain parts of our technology in conjunction with other lentiviral vectors you may already have. Finally, each system is available with either an ecotropic or a pantropic envelope vector.

ViraSafe™ vector technologies are available in the following formats: