AAV-KP1 Rep-Cap Plasmid

AAV-KP1 Rep-Cap Plasmid
  • Use this AAV Rep-Cap plasmid along with the AAV Helper Free System to produce recombinant human adeno associated virus (rAAV) virions without the need for a helper virus
  • Ideal if you already have the AAV Helper Free System with a different AAV serotype
  • Increased transduction efficiency of primary human islet cells and human embryonic stem cell–derived β cells


NOTE: pAAV-KP1 is available for sale to academic, government and non-profit research laboratories. All other purchasers require a commercial license for all fields including research use. Please contact our Business Development department for license information.

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AAV-KP1 Rep-Cap Plasmid
Catalog Number
10 µg
Manual/Data Sheet Download
SDS Download
Map Download
Sequence Download
Product Details

Adeno-associated virus (AAV) serotypes differ broadly in transduction efficacies and tissue tropisms.  Capsid shuffled barcoded AAV libraries are subjected to multiple rounds of selection on primary human islets and analyzed enriched capsid variants for improved transduction efficiency.  AAV-KP1 is found and it facilitates transduction of primary human islet cells and human embryonic stem cell–derived β cells with up to 10-fold higher efficiency compared with previously studied best-in-class AAV vectors.  In addition, AAV-KP1 shows improved transduction in other nonpancreatic cell types both in vitro and in vivo.