The protein makeup of SARS-CoV-2 includes a membrane glycoprotein, envelope protein, spike protein, and the nucleocapsid (N) protein. The N protein is an RNA binding protein which binds the RNA genome of the virus and packages it into a long helix-containing nucleocapsid structure called a ribonucleoprotein (RNP) complex. The N protein has been shown to be important for keeping the RNA in a highly ordered conformation to facilitate replication and transcription of the viral genome. It is also responsible for regulating interactions with the host such as actin reorganization, apoptosis, and cell cycle regulation.
Our SARS-CoV-2 Nucleocapsid ELISA Kit is an enzyme immunoassay developed for the detection and quantitation of N protein in SARS-CoV-2. The kit has a detection sensitivity limit of 1.25 ng/mL. Each kit provides sufficient reagents to perform up to 96 assays including standards and unknown samples.