Tumor Transendothelial Migration Assay

  • Quantify interactions between endothelium and tumor cells
  • Fully quantify cell transmigration with no manual cell counting
  • Highly sensitive results on a fluorescence plate reader

 

Frequently Asked Questions about this product

Email To BuyerPrint this PageCopy Link
Ordering

Please contact your distributor for pricing.

CytoSelect™ Tumor Transendothelial Migration Assay
Catalog Number
CBA-216
Size
24 assays
Detection
Fluorometric
Manual/Data Sheet Download
SDS Download
Price
$595.00
Product Details

Cancer cell transmigration, particularly extravasation, is an important step in cancer metastasis. It is the final step in a cascade of interactions between cells and the endothelium.

CytoSelect™ Tumor Transendothelial Migration Assay provides a robust system for the quantitative determination of transmigrations and interactions between endothelium and tumor cells. Migratory cells may be quantified on a fluorescence plate reader. Kits use 24-well plates with 8 µm pore size membrane inserts.

Recent Product Citations
  1. Fife, C. M. et al. (2016). Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration. Oncogene. doi:10.1038/onc.2016.220.
  2. Waghray, M. et al. (2016). GM-CSF mediates mesenchymal-epithelial crosstalk in pancreatic cancer. Cancer Discov. Doi:10.1158/2159-8290.CD-15-0947.
  3. Park, G. B. et al. (2015). Regulation of ADAM10 and ADAM17 by sorafenib inhibits epithelial-to-mesenchymal transition in Epstein-Barr virus–infected retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 56:5162-5173.
  4. Park, G. B. et al. (2015). Silencing of galectin-3 represses osteosarcoma cell migration and invasion through inhibition of FAK/Src/Lyn activation and β-catenin expression and increases susceptibility to chemotherapeutic agents.Int J Oncol. 46:185-194.
  5. Choi, S. H. et al. (2014). MMP9 processing of HSPB1 regulates tumor progression. PLoS One.  9:e85509.
  6. Haidari, M. et al. (2014). Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-β-dependent vascular endothelial cadherin tyrosine phosphorylation. Cardiovasc Diabetol. 13:112.
  7. Park, G.B. et al. (2014). The Epstein-Barr virus causes epithelial-mesenchymal transition in human corneal epithelial cells via Syk/Src and Akt/Erk signaling pathways.Invest. Ophthalmol. Vis. Sci. 55:1770-1779.
  8. Xu, Z. et al. (2010). Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis. Am. J. Pathol., 177:2585-2596 (#CBA-216)
  9. Yang, H. and H.E. Grossniklaus (2010). Constitutive Overexpression of Pigment Epithelium Derived Factor Inhibition of Ocular Melanoma Growth and Metastasis. Invest. Ophthalmol. Vis. Sci. 51:28-34 (#CBA-216).
  10. Liu, K. et al. (2007). Lentivirus Mediated Gene Transfer of PEDF Results in Decreased Uveal Melanoma Transendothelial Migration. Invest. Opthalmol. Vis. Sci. 48:5244 (#CBA-216).