UV Induced DNA Damage Assays
DNA may be damaged by ultraviolet light resulting in the formation of two structures: cyclobutane pyrimidine dimers (CPD) and pyrimidine (6-4) pyrimidone photoproducts (6-4PP). The result is a mutation of C to T and CC to TT, which are the most prevalent mutations in p53 found in human and mouse skin cancers.
We offer assays to quantify either CPD or 6-4PP in three formats:
- ELISA kits for use with intact cells
- ELISA kits for DNA isolated from cells or tissues
- Immunofluorescence staining kit
If you are interested in studying both damage structures, consider our CPD and 6-4PP ELISA Combo Kit for use on isolated DNA.