Lipoprotein Metabolism

Lipoproteins are important protein-lipid assemblies that are responsible for the transport of fats to different parts of the body via the bloodstream. The five major groups of lipoproteins are very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), intermediate-density lipoprotein (IDL), high-density lipoprotein (HDL), and chylomicrons. LDL and HDL are of particular interest due to their impact on human health.

Lipoproteins are composed of lipids and proteins which are held together by noncovalent forces. The outer layer consists of phospholipids, unesterified cholesterol, and proteins; the neutral lipid core is composed predominately of cholesteryl esters and triacylglycerols (TAG). Apolipoproteins are the proteins that, along with other amphipathic molecules, surround the lipids to make up the lipoproteins. This association allows lipoproteins to be carried through water-based circulation, specifically blood and lymph.

Our assays include simple, convenient tests to measure levels of cholesterols, fatty acids, phospholipids, and bile acids. We also offer a variety of kits to isolate and quantify lipids, as well as to purify lipoproteins.